Did your South Carolina ancestors live in the area which was the Orangeburgh District from 1768 to 1868? This area later became split and/or redistricted to the following counties: Orangeburg, Barnwell, Lexington, Aiken, Calhoun. The Edisto River is a major feature, geographically.
Many of the settlers in this area were of German-Swiss, English-Scottish-Irish, or French Huguenot descent, as well as the many Africans that were enslaved.
I invite you to list your families from this part of South Carolina and, if you can, any families they intermarried with so that we can help one another in our research.