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The furthest back I find [so far] is Mary Carter (her mother's name was also Mary, but I don't know her maiden name - she was married to Joseph Carter), born about 1800 in Maryland, US - married William Ammons.
My maternal grandmother always claimed that her ancestors were from "the south of France." But other relatives swear that they were actually Native American - Quapaw, an offshoot of Cherokee. I believe my great-grandmother even lived on a reservation as a child.
Haplogroup U5 and its subclades U5a and U5b form the highest population concentrations in the far north, in Sami, Finns, and Estonians, but it is spread widely at lower levels throughout Europe. This distribution, and the age of the haplogroup, indicate individuals from this haplogroup were part of the initial expansion tracking the retreat of ice sheets from Europe ~10kya.
Haplogroup U5 is found also in small frequencies and at much lower diversity in the Near East and parts of Africa, suggesting back-migration of people from northern Europe to the south.
I know that there are supposedly only 4 or 5 Native American haplogroups (U is not on that list), but I've read other accounts of Native American ancestry by U5-ers. I have also read that, when studying tribes, if scientists encounter a haplogroup they were not expecting, they discount it as "mixing."