My main surname of interest in the Valley is Roush (originally Rausch). They were in Frederick & Shenandoah counties in the mid- and late-1700's. Surnames of spouses from the Valley include Zerkel/Zirkle, Fuchs (Fox), and Kelchner.
HAYS: My direct paternal ancestor John Hays (wife Rebecca) purchased land in the Borden Tract in 1740. He built his plantation just two miles north of Rockbridge Baths. It was there on a natural mill site, where Hays Creek and Moffett's Creek ran together, that John Hays built the first fulling mill in what later become Rockbridge County (est. 1778).