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William McGuffin came to America from Northern Ireland before 1790.  He settled with his family in Old Pendleton District, South Carolina.  His daughter, Elizabeth, married my 3rd GGF (Hugh Williams) in 1807 in Pendleton. 

After his death, Elizabeth (and children) moved with three of her brothers to Texas in about 1827.  Hugh Moses McGuffin and his brothers arrived before the Texas Revolution and played important roles during that time.  After the war, they served Texas well as public servants and the development of new counties.

I am still researching this family and would love to have your input and learn about your McGuffin families in America and Ireland.

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Hugh Moses McGuffin became a great friend to Stephen F Austin and his family.  Here's how they met:

https://www.tshaonline.org/handbook/online/articles/fmc64

MCGUFFIN, HUGH (ca. 1780–?). Hugh McGuffin, a native of Ireland, was born around 1780. In 1820 he lived near Camp Sabine in East Texas. Moses Austin, on a return trip from San Antonio to Missouri in 1820, became ill with pneumonia and recuperated in McGuffin's home for several weeks. Later, McGuffin wrote Stephen F. Austin of an interest in moving to his colony. He did so in the 1820s. In Washington County he was elected justice of the peace in 1836. Montgomery County was established in December 1837, and McGuffin served the new county as associate land commissioner in 1839 and chief justice in 1840. That year he owned 1,442 acres in Montgomery County, one slave, two horses, and ten cattle. After statehood he continued to take active part in Texas affairs. When Madison County was separated from Montgomery County in 1853, McGuffin ran a successful campaign in the May election for the post of notary public. He was reelected in January 1854. He married Delphina Earl about 1835. She died in 1846. The 1850 census listed McGuffin's age as seventy.

BIBLIOGRAPHY: 

James Milton Carroll, A History of Texas Baptists (Dallas: Baptist Standard, 1923). Marion Day Mullins, First Census of Texas, 1829–1836, and Other Early Records of the Republic of Texas (Washington: National Genealogical Society, 1959). Worth Stickley Ray, Austin Colony Pioneers (Austin: Jenkins, 1949; 2d ed., Austin: Pemberton, 1970). Texas House of Representatives, Biographical Directory of the Texan Conventions and Congresses, 1832–1845 (Austin: Book Exchange, 1941). Gifford E. White, ed., The 1840 Census of the Republic of Texas (Austin: Pemberton, 1966; 2d ed., Vol. 2 of 1840 Citizens of Texas, Austin, 1984). Gifford E. White, 1830 Citizens of Texas (Austin: Eakin, 1983). Gifford E. White, 1840 Citizens of Texas (2 vols., Austin, 1983–84).

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